Author's response to reviews Title:Non-Small Cell Lung Cancer with EML4-ALK Translocation in Chinese Male Never-Smokers is Characterized with Early-Onset Authors:
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EML4-ALK translocation is associated with early onset of disease and other clinicopathological features in Chinese female never-smokers with non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC) with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) translocation is resistant to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), including gefitinib and erlotinib, but responds to the ALK-TKI crizotinib. Characterization of EML4-ALK translocation may provide invaluable information to facilitat...
متن کاملClinical Significance of EML4-ALK Fusion Gene and Association with EGFR and KRAS Gene Mutations in 208 Chinese Patients with Non-Small Cell Lung Cancer
The EML4-ALK fusion gene has been recently identified in a small subset of non-small cell lung cancer (NSCLC) patients who respond positively to ALK inhibitors. The characteristics of the EML4-ALK fusion gene in Chinese patients with NSCLC are poorly understood. Here, we report on the prevalence of EML4-ALK, EGFR status and KRAS mutations in 208 Chinese patients with NSCLC. EGFR mutations were ...
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Author's disclosures of potential conflict of interest are found at the end of this article. Review of " Anaplastic lymphoma ki-nase inhibition in non–small-cell lung cancer, " by Kwak et al. For a discussion of waterfall plots, both in general and how they are used in the Kwak et al. article, see the related article by Theresa Gillespie, PhD, MA, RN, on page 106. L ung cancer is the number 1 c...
متن کاملElderly male smokers with right lung tumors are viable candidates for KRAS mutation screening
Genetic aberrations in tumor driver genes provide specific molecular targets for therapeutic intervention, which can greatly improve therapeutic outcomes. Here, we analyzed the mutational frequency of EGFR and KRAS gene, as well as EML4-ALK rearrangement, and summarized the clinicopathological characters of Chinese lung cancer patients. We detected the mutation spectrum of 1033 primary lung can...
متن کاملEML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.
PURPOSE The EML4-ALK fusion gene has been detected in approximately 7% of Japanese non-small cell lung cancers (NSCLC). We determined the frequency of EML4-ALK in Caucasian NSCLC and in NSCLC cell lines. We also determined whether TAE684, a specific ALK kinase inhibitor, would inhibit the growth of EML4-ALK-containing cell lines in vitro and in vivo. EXPERIMENTAL DESIGN We screened 305 primar...
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تاریخ انتشار 2014